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Acute anterior uveitis

MedGen UID:
472531
•Concept ID:
C0701807
•
Disease or Syndrome
Synonym: Uveitis anterior acuta
SNOMED CT: AAU - acute anterior uveitis (4927003); Acute anterior uveitis (4927003)

Definition

Sudden onset of anterior uveitis, usually unilateral, and associated with pain, erythema, photophobia, and blurred vision. Often associated with HLA-B27, with or without co-existing spondyloarthritis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute anterior uveitis

Professional guidelines

PubMed

HLA-B27-positive anterior uveitis : Clinical aspects, diagnostics, interdisciplinary management, and treatment.
Werkl P, Rademacher J, Pleyer U
Ophthalmologie 2024 Jan;121(Suppl 1):12-22. Epub 2023 Dec 12 doi: 10.1007/s00347-023-01960-z. PMID: 38085287
Uveitis-Glaucoma-Hyphema Syndrome: Clinical Features and Differential Diagnosis.
Accorinti M, Saturno MC, Paroli MP, De Geronimo D, Gilardi M
Ocul Immunol Inflamm 2022 Aug;30(6):1408-1413. Epub 2021 Apr 1 doi: 10.1080/09273948.2021.1881563. PMID: 33793379
The Management of Acute Anterior Uveitis Complicating Spondyloarthritis: Present and Future.
Biggioggero M, Crotti C, Becciolini A, Miserocchi E, Favalli EG
Biomed Res Int 2018;2018:9460187. Epub 2018 Oct 14 doi: 10.1155/2018/9460187. PMID: 30406148Free PMC Article

Recent clinical studies

Etiology

Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics.
Chen S, Huang W, Wan Q, Tang Z, Li X, Zeng F, Zheng S, Li Z, Liu X
J Transl Med 2024 Mar 12;22(1):271. doi: 10.1186/s12967-024-05077-y. PMID: 38475831Free PMC Article
Axial spondyloarthritis: one year in review 2023.
Fattorini F, Gentileschi S, Cigolini C, Terenzi R, Pata AP, Esti L, Carli L
Clin Exp Rheumatol 2023 Nov;41(11):2142-2150. Epub 2023 Nov 14 doi: 10.55563/clinexprheumatol/9fhz98. PMID: 37965699
Targeted depletion of TRBV9(+) T cells as immunotherapy in a patient with ankylosing spondylitis.
Britanova OV, Lupyr KR, Staroverov DB, Shagina IA, Aleksandrov AA, Ustyugov YY, Somov DV, Klimenko A, Shostak NA, Zvyagin IV, Stepanov AV, Merzlyak EM, Davydov AN, Izraelson M, Egorov ES, Bogdanova EA, Vladimirova AK, Iakovlev PA, Fedorenko DA, Ivanov RA, Skvortsova VI, Lukyanov S, Chudakov DM
Nat Med 2023 Nov;29(11):2731-2736. Epub 2023 Oct 23 doi: 10.1038/s41591-023-02613-z. PMID: 37872223Free PMC Article
Psoriatic arthritis: one year in review 2022.
Cigolini C, Fattorini F, Gentileschi S, Terenzi R, Carli L
Clin Exp Rheumatol 2022 Sep;40(9):1611-1619. Epub 2022 Sep 19 doi: 10.55563/clinexprheumatol/x3sfxe. PMID: 36129799
Enthesitis-related arthritis.
Aggarwal A, Misra DP
Clin Rheumatol 2015 Nov;34(11):1839-46. Epub 2015 Aug 2 doi: 10.1007/s10067-015-3029-4. PMID: 26233720

Diagnosis

Extra-articular Manifestations of Chikungunya.
Oliveira JL, Nogueira IA, Amaral JK, Campos LR, Mendonça MMM, Ricarte MB, Cavalcanti LPG, Schoen RT
Rev Soc Bras Med Trop 2023;56:0341. Epub 2023 Dec 8 doi: 10.1590/0037-8682-0341-2023. PMID: 38088664Free PMC Article
Psoriatic arthritis: one year in review 2022.
Cigolini C, Fattorini F, Gentileschi S, Terenzi R, Carli L
Clin Exp Rheumatol 2022 Sep;40(9):1611-1619. Epub 2022 Sep 19 doi: 10.55563/clinexprheumatol/x3sfxe. PMID: 36129799
The eye in spondyloarthritis(✰).
Rosenbaum JT
Semin Arthritis Rheum 2019 Dec;49(3S):S29-S31. doi: 10.1016/j.semarthrit.2019.09.014. PMID: 31779847Free PMC Article
Enthesitis-related arthritis.
Aggarwal A, Misra DP
Clin Rheumatol 2015 Nov;34(11):1839-46. Epub 2015 Aug 2 doi: 10.1007/s10067-015-3029-4. PMID: 26233720
Acute anterior uveitis.
Curi A, Matos K, Pavesio C
Clin Evid 2002 Jun;(7):555-9. PMID: 12230681

Therapy

Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics.
Chen S, Huang W, Wan Q, Tang Z, Li X, Zeng F, Zheng S, Li Z, Liu X
J Transl Med 2024 Mar 12;22(1):271. doi: 10.1186/s12967-024-05077-y. PMID: 38475831Free PMC Article
Targeted depletion of TRBV9(+) T cells as immunotherapy in a patient with ankylosing spondylitis.
Britanova OV, Lupyr KR, Staroverov DB, Shagina IA, Aleksandrov AA, Ustyugov YY, Somov DV, Klimenko A, Shostak NA, Zvyagin IV, Stepanov AV, Merzlyak EM, Davydov AN, Izraelson M, Egorov ES, Bogdanova EA, Vladimirova AK, Iakovlev PA, Fedorenko DA, Ivanov RA, Skvortsova VI, Lukyanov S, Chudakov DM
Nat Med 2023 Nov;29(11):2731-2736. Epub 2023 Oct 23 doi: 10.1038/s41591-023-02613-z. PMID: 37872223Free PMC Article
Recent Developments in HLA B27 Anterior Uveitis.
Wakefield D, Clarke D, McCluskey P
Front Immunol 2020;11:608134. Epub 2021 Jan 5 doi: 10.3389/fimmu.2020.608134. PMID: 33469457Free PMC Article
The eye in spondyloarthritis(✰).
Rosenbaum JT
Semin Arthritis Rheum 2019 Dec;49(3S):S29-S31. doi: 10.1016/j.semarthrit.2019.09.014. PMID: 31779847Free PMC Article
Enthesitis-related arthritis.
Aggarwal A, Misra DP
Clin Rheumatol 2015 Nov;34(11):1839-46. Epub 2015 Aug 2 doi: 10.1007/s10067-015-3029-4. PMID: 26233720

Prognosis

Genetics and the axial spondyloarthritis spectrum.
Brown MA, Xu H, Li Z
Rheumatology (Oxford) 2020 Oct 1;59(Suppl4):iv58-iv66. doi: 10.1093/rheumatology/keaa464. PMID: 33053195Free PMC Article
Enthesitis-related arthritis.
Aggarwal A, Misra DP
Clin Rheumatol 2015 Nov;34(11):1839-46. Epub 2015 Aug 2 doi: 10.1007/s10067-015-3029-4. PMID: 26233720
Acute Anterior Uveitis and Spondyloarthritis: More Than Meets the Eye.
Khan MA, Haroon M, Rosenbaum JT
Curr Rheumatol Rep 2015 Sep;17(9):59. doi: 10.1007/s11926-015-0536-x. PMID: 26233598
Uveitis (acute anterior).
Islam N, Pavesio C
BMJ Clin Evid 2010 Apr 8;2010 PMID: 21736765Free PMC Article
Uveitis.
Muñoz-Fernández S, Martín-Mola E
Best Pract Res Clin Rheumatol 2006 Jun;20(3):487-505. doi: 10.1016/j.berh.2006.03.008. PMID: 16777578

Clinical prediction guides

Targeted depletion of TRBV9(+) T cells as immunotherapy in a patient with ankylosing spondylitis.
Britanova OV, Lupyr KR, Staroverov DB, Shagina IA, Aleksandrov AA, Ustyugov YY, Somov DV, Klimenko A, Shostak NA, Zvyagin IV, Stepanov AV, Merzlyak EM, Davydov AN, Izraelson M, Egorov ES, Bogdanova EA, Vladimirova AK, Iakovlev PA, Fedorenko DA, Ivanov RA, Skvortsova VI, Lukyanov S, Chudakov DM
Nat Med 2023 Nov;29(11):2731-2736. Epub 2023 Oct 23 doi: 10.1038/s41591-023-02613-z. PMID: 37872223Free PMC Article
Ophthalmological findings in brucellosis.
Karakurt Y, Karakeçili F
J Fr Ophtalmol 2023 Sep;46(7):769-775. Epub 2023 Aug 2 doi: 10.1016/j.jfo.2023.02.017. PMID: 37541801
Genetics and the axial spondyloarthritis spectrum.
Brown MA, Xu H, Li Z
Rheumatology (Oxford) 2020 Oct 1;59(Suppl4):iv58-iv66. doi: 10.1093/rheumatology/keaa464. PMID: 33053195Free PMC Article
HLA-B27 Anterior Uveitis: Immunology and Immunopathology.
Wakefield D, Yates W, Amjadi S, McCluskey P
Ocul Immunol Inflamm 2016 Aug;24(4):450-9. Epub 2016 May 31 doi: 10.3109/09273948.2016.1158283. PMID: 27245590
Uveitis (acute anterior).
Islam N, Pavesio C
BMJ Clin Evid 2010 Apr 8;2010 PMID: 21736765Free PMC Article

Recent systematic reviews

Uveitis (acute anterior).
Islam N, Pavesio C
BMJ Clin Evid 2010 Apr 8;2010 PMID: 21736765Free PMC Article
Uveitis (acute anterior).
Islam N, Pavesio C
BMJ Clin Evid 2007 Aug 15;2007 PMID: 19454114

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